Search results for "Analgesic activity"
showing 2 items of 2 documents
Anti-inflammatory and analgesic activities of flavonoid and saponin fractions from Zizyphus lotus (L.) Lam.
2008
Abstract The effect of the flavonoid and saponin fractions from the leaves and root bark of Zizyphus lotus (200 mg/kg) was evaluated on carrageenan-induced paw edema in rats and on acetic acid-induced algesia in mice. In addition, two methanolic extracts from the plant (1 mg/ear) were tested on oxazolone-induced contact-delayed hypersensitivity (DTH) in mice. The effect of the different fractions was also evaluated in vitro on the nitrite production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages. The results showed that both the flavonoid and saponin fractions significantly inhibited paw edema, algesia, and nitrite production without affecting cell viability. Furthermore, the …
Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product
2021
This study aimed to determine the composition and content of polyphenols in the dry extract obtained from the hydrodistilled residue by-product of the wild bergamot (Monarda fistulosa L., Lamiaceae Martinov family) herb (MFDE) and to evaluate its safety and pharmacological properties. The total phenolic content (TPC) in the MFDE was 120.64 mg GAE/g. The high-performance liquid chromatography (HPLC) analysis showed the presence of a plethora of phenolic compounds, including hydroxycinnamic acids and flavone derivatives in the MFDE, with rosmarinic acid and luteolin-7-O-glucoside being the main components. With an IC50 value of 0.285 mg/mL, it was found to be a strong DPPH radical scavenger. …